Gallery of Structures Solved in the Lab
(click on image for an enlarged view)
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Recognition of RCC1 by importin a3 and Kap60
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Sankhala et al.,
Nature Comm, 2017
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Inhibition of COX-1 by Mofezolac and P6
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Cingolani et al.,
Eur. J. Med. Chem, 2017
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Immature ProCapsid Portal Protein
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Lokareddy et al.,
Nature Comm, 2017
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| HK620 and P22 tail needles crystallized at different pHs |
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PDB entries: 4ZKP, 4ZKU, 4ZXQ, 5BU5, 5BVZ, 5BU8 Bhardwaj et al.,
J. Biol. Chemistry, 2016
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| Pom121 membrane protein NLS bound to importin α |
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PDB entry: 4YI0 Kralt et al.,
Mol. Cell. Bio., 2017
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| Heh1 and Heh2 membrane protein NLS bound to yeast importin a |
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Lokareddy et al.,
Structure, 2015
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Mycobacterium Tuberculosis TNT-IFT Complex |
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PDB entry: 4QLP Sun et al.,
Nat. Struct. Mol. Biol., 2015
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Importin α isoforms 1, 3, 7 bound to Influenza PB2 |
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Pumroy et al.,
Structure, 2015
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Phosphatase domain of Human Laforin |
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PDB entry: 4R30 Sankhala et al.,
J. Biol. Chemistry, 2015
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| Human RNA Phosphatase PIR1 |
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Sankhala et al.,
Biochemistry, 2014
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Human p53-phosphatase
DUSP26
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PDB entry: 4HRF Lokareddy et al.,
Biochemistry, 2013
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| P22 Headful Packaging Nuclease |
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PDB entry: 4DKW Roy et al.,
J. Biol. Chemistry, 2012
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| Human Importin α5 bound to Nup50 |
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PDB entry: 3TJ3 Ruth et al.,
J. Biol. Chemistry, 2012
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P22 nonameric
Small terminase subunit
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PDB entry: 3P9A Roy et al.,
Structure, 2012
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| Mammalian Importin α1 bound to PLSCR4 minimal NLS |
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PDB entry: 3Q5U Lott et al.,
J. Biol. Chemistry, 2011
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E.coli F1 ATPase inhibited by subunit ε |
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PDB entry: 3OAA Cingolani and Duncan,
Nat. Struct. Mol. Biol., 2011
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Structure of phage Sf6 Tail Needle Knob |
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Bhardwaj et al.,
J. Biol. Chemistry, 2011
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| Full length dodecameric P22 Portal Protein |
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PDB entry: 3LJ5 Olia et al.,
Nat. Struct. Mol. Biol., 2011
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| Dodecameric P22 Portal Protein Core bound to twelve GP4s |
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Olia et al.,
Nat. Struct. Mol. Biol., 2011
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| Open and closed conformation of Importin β:sIBB complex |
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PDB entry: 3LWW Bhardwaj et al.,
Biochemistry, 2010
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A circular permutant of
Barnase
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PDB entry: 3DA7 Butler et al.,
Biochemistry, 2009
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| Vaccinia Virus Dual Specificity Phosphatase VH1 |
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Koksal et al.,
J. Biol. Chemistry, 2009
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| Phage P22 Tail Needle Gp26 |
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Olia et al.,
Nat. Struct. Mol. Biol., 2007
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| Human Importin β bound to snurportin IBB-domain |
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Mitrousis et al.,
J. Biol. Chemistry, 2008
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| Mammalian Importin α bound to Scramblase 1 NLS |
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PDB entry: 1Y2A Chen et al.,
J. Biol. Chemistry, 2005
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| Human Importin β HEATs (1-11) bound to the PTHrP-NLS |
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PDB entry: 1M5N Cingolani et al.,
Molecular Cell, 2002
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| Human Importin β bound to importin α IBB-domain |
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Cingolani et al.,
Nature, 1999
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