FEBs-2000Nature-1999        EMBOj-2005        MolCELL-2008        Structure-2012                 

Publications

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2018

76. Rodriguez-Bravo, V., Pippa, R., Song, W.M., Carceles-Cordon, M., Dominguez-Andres, A., Fujiwara, N., Woo, J., Koh, A.P., Ertel, A., Lokareddy, R.K., Cuesta-Dominguez, A., Kim, R.S., Rodriguez-Fernandez, I., Li, P., Gordon, R., Hirschfield, H., Prats, J.M., Reddy, E.P., Fatatis, A., Petrylak, D.P., Gomella, L., Kelly, W.K., Lowe, S.W., Knudsen, K.E., Galsky, M.D., Cingolani, G., Lujambio, A., Hoshida, Y., Domingo-Domenech, J. (2018) Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. Cell. 174(5):1200-1215.

75. Parent, K.N., Schrad J.R. and Cingolani, G. (2018) Breaking symmetry in viral icosahedral capsids as seen through the lenses of X-ray crystallography and cryo-electron microscopy. Viruses, 10(2). pii: E67. PMCID: PMC5850374

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2017

74. Sankhala, R.S., Lokareddy, R.K., Begum S., Pumroy, A.R., Gillilan, E.R. and Cingolani, G. (2017) Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1Nature Commun. 8(1):979. PMCID: PMC5645467

73. Wu, W., Sankhala, S.R., Florio, J.T., Zhou, L., Nguyen, L.T.N., Lokareddy, R.K.Cingolani, G. and Pante, N. (2017) Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms. Scientific Reports. 17(1):11381. PMCID: PMC5595889

72. Cingolani, G., Panella, A., Perrone, MG., Vitale, P., Di Mauro, G., Fortuna, C., Armen, R., Ferorelli, S., Smith, W. and Scilimati, A. (2017) Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6). Eur J Med Chem. 138:661-668. PMCID: PMC5992922

71. Motwani, T., Lokareddy, R.K., Dunbar, A.C., Cortines, R.J., Jarrold, F. M., Cingolani, G. and Teschke, C.M. (2017) A viral scaffolding protein triggers portal ring oligomerization and incorporation during procapsid assembly. Science Advances. 3: e1700423. PMCID: PMC5529062

70. Lokareddy, R.K., Sankhala, R.S., Roy, A., Afonine, P.V., Motwani, T., Teschke, C.M., Parent, K.N. and Cingolani, G. (2017) Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation. Nature Commun. 8:14310. PMCID: PMC5290284

69. Rogers, C., Fernandes-Alnemri, T., Mayes, L., Alnemri, D., Cingolani, G. and Alnemri, E.S. (2017) Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. Nature Commun. 8:14128. PMCID: PMC5216131

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2016

68. Sankhala, R.S., Lokareddy, R.K. and Cingolani, G. (2016) Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits. J Biol Chem. 291(21):11420-33. PMCID: PMC4900285

67. Riccio, A.A., Cingolani, G. and Pascal, J.M. (2016) PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage. Nucleic Acids Res. 44(4):1691-702. PMCID: PMC4770219

66. Bhardwaj, A., Sankhala, R.S., Olia, A.S., Brooke, D., Casjens, S.R., Taylor, J.D., Prevelige, P.E. Jr. and Cingolani, G. (2016) Structural plasticity of the protein plug that traps newly packaged genomes in podoviridae virions. J Biol Chem. 291(1):215-26. PMCID: PMC4697157

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2015

65. Sankhala, R.S., Lokareddy, R.K. and Cingolani, G. (2015) A Greasy Aid to Capsid Assembly: Lessons from a Salty Virus. Structure. 23(10):1777-1779. PMID: 26445488

64. McNulty, R., Lokareddy, R.K., Roy, A., Yang, Y., Lander, G., Heck, A.J., Johnson, J.E. and Cingolani, G. (2015) Architecture of the Complex formed by Large and Small Terminase Subunits from Bacteriophage P22. J. Mol. Biol. 427(20):3285-99PMCID: PMC4587339

63. Sun, J., Siroy, A., Lokareddy, K.R., Speer, A., Doornbos, K.S., Cingolani, G. and Niederweis, M. (2015) The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD+. Nature Struc Mol Biol. 22(9):672-8. PMCID: PMC4560639

62. Kralt, A., Jagalur, N.B., van den Boom, V., Lokareddy, R.K., Steen, A., Cingolani, G., Fornerod, M., Veenhoff, L.M. (2015) Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins. Mol Biol Cell. 26(18):3301-12. PMCID: PMC4569319

61. Hwang, B., McCool, K., Wan, J., Wuerzberger-Davis, S.M., Young, E.W., Choi, E.Y., Cingolani, G., Weaver, B.A., Miyamoto, S.(2015) IPO3 mediated nonclassical nuclear import of NEMO drives DNA damage-dependent NF-κB activation. J Biol Chem. 290(29):17967-84. PMCID: PMC4505044

60. Liao, Z., Gu, L., Vergalli, J., Mariani, S.A., De Dominici, M., Lokareddy, R.K., Dagvadorj, A., Purushottamachar, P., McCue, P.A., Trabulsi, E., Lallas, C.D., Gupta, S., Ellsworth, E., Blackmon, S., Ertel, A., Fortina, P., Leiby, B., Xia, G., Rui, H., Hoang, D.T., Gomella, L.G., Cingolani, G., Njar, V., Pattabiraman, N., Calabretta, B., Nevalainen, M.T. (2015) Structure-based screen identifies a potent small-molecule inhibitor of Stat5a/b with therapeutic potential for prostate cancer and chronic myeloid leukemia. Mol Cancer Ther. 14:1777-1793PMCID: PMC4547362

59. Lokareddy, K.R., Hapsari R.A., van Rheenen, M., Pumroy, R.A., Bhardwaj, A., Steen, A., Veenhoff, L.M. and Cingolani, G. (2015) Distinctive properties of the Nuclear Localization Signals of Inner Nuclear Membrane proteins Heh1 and Heh2Structure. 23(7):1305-16. PMCID: PMC4768490

58. Sankhala, S.R., Koksal, C.A., Ho, L., Nitschke, F., Minassian, A.B. and Cingolani, G. (2015) Dimeric quaternary structure of human laforin. J Biol Chem. 290(8):4552-559. PMCID: PMC4335197

57. Pumroy, R.A. and Cingolani, G. (2015) Diversification of importin alpha isoforms in cellular trafficking and disease state. Biochemical J. 466(1):13-28. PMCID: PMC4405237

56. Pumroy, R.A., Ke, S., Hart, D.J., Zachariae, U. and Cingolani, G. (2015) Molecular determinants for nuclear import of Influenza A PB2 by importin α isoforms 3 and 7. Structure. 23(2): 374-384. PMCID: PMC4346194

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2014

55. Aggeli, D., Kish-Trier, E., Lin, M.C., Haarer, B., Cingolani, G., Cooper, J.A., Wilkens, S. and Amberg, D.C. (2014) Coordination of the Filament Stabilizing Versus Destabilizing Activities of Cofilin Through its Secondary Binding Site on Actin. Cytoskeleton. 71(6):361-79. PMCID: PMC4241054

54. Lieu, K.G., Shim, E.H., Wang, J., Lokareddy, R.K., Tao, T., Cingolani, G. Zambetti, G.P. and Jans, D.A. (2014) The p53-induced Factor Ei24 Inhibits Nuclear Import through an Importin beta-binding-like Domain. J. Cell Biol. 205(3):301-12. PMCID: PMC4018778

53. Sankhala, S.R., Lokareddy, K.R. and Cingolani, G. (2014) Structure of Human PIR1, an Atypical Dual Specificity Phosphatase. Biochemistry. 53(5):862-71. PMCID: PMC3985963

52. Bhardwaj, A., Casjens, S.R. and Cingolani, G. (2014) Exploring the atomic structure and conformational flexibility of a 320A long engineered viral fiber using X-ray crystallography. Acta Cryst. D70: 342-353. PMCID: PMC3940195

51. Bhardwaj, A., Olia, A.S. and Cingolani, G. (2014) Architecture of Viral Genome-Delivery Molecular Machines. Curr Opin Struct Biol. 25:1-8. PMCID: PMC4040186

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2013

50. Pumroy, R. and Cingolani, G. (2013) Jamming up the "beta-staple": Regulation of SIRT1 activity by its C-terminal regulatory segment (CTR). J. Mol. Biol. pii: S0022-2836(13)00724-9. PMCID: PMC4405232

49. Smith F.J., Pau, V.P., Cingolani, G., and Rothberg, B.S. (2013) Structural basis of allosteric interactions among Ca2+-binding sites in a K+ channel RCK domain. Nature Commun. 4:2621. PMID: 24126388

48. Leavitt, J.C. Gogokhia, L., Gilcrease, E.B., Bhardwaj, A., Cingolani, G. and Casjens, S.R. (2013) The tip of the tail needle affects the rate of DNA delivery by bacteriophage P22. PLOS One. 8(8):e70936PMCID: PMC3741392

47. Lokareddy, K.R., Bhardwaj, A. and Cingolani, G. (2013) Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase. Biochemistry. 52(5):938-48. PMCID: PMC3619938

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2012

46. Smith, F.J., Pau, V.P., Cingolani, G. and Rothberg, B.S. (2012) Crystal Structure of a Ba2+-bound gating ring reveals elementary steps in RCK domain activation. Structure. 20(12):2038-47. PMCID: PMC3518701

45. Roy, A., Hutcheon, L., Duncan, T.M. and Cingolani, G. (2012) Improved crystallization of Escherichia coli ATP synthase catalytic complex (F1) by introducing a phosphomimetic mutation in subunit ε. Acta Cryst. F. 68, 1229-1233. PMCID: PMC3490465

44. Roy, A. and Cingolani, G. (2012) Structure of P22 headful packaging nuclease. J Biol Chem. 287(33):28196-205. PMCID: PMC3431676

43. Roy, A., Bhardwaj, A., Datta, P., Lander, G.C. and Cingolani, G. (2012) Small terminase couples viral DNA-binding to genome-packaging ATPase activity. Structure. 20(8):1403-13. PMCID: PMC3563279

42. Pumroy, R.A., Nardozzi, J., Hart, D.J., Root, M.J. and Cingolani, G. (2012) Nup50 stabilizes the closed conformation of arm 10 in importin a5. J Biol Chem. 287(3):2022-31. PMCID: PMC3265882

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 2011

41. Lott, K., Bhardwaj, A., Sims, P. and Cingolani, G. (2011) A minimal Nuclear Localization Signal in human phospholipid Scramblase 4 that binds only the minor binding site in importin a. J Biol Chem. 286(32):28160-9. PMCID: PMC3151061

40. Bhardwaj, A., Molineux, J.I., Casjens, S.R. and Cingolani, G. (2011) Atomic Structure of Sf6 Tail Needle Knob. J Biol Chem. 286(35):30867-77. PMCID: PMC3162447

39. Cingolani, G. and Duncan, T.M. (2011) Structure of the ATP synthase catalytic complex (F1) from Escherichia coli in an auto-inhibited conformation. Nature Struc Mol Biol. 18(6):701-7. PMCID: PMC3109198. Faculty of 1000 “exceptional read”.

38. Olia, A.S, Prevelige Jr., P.E., Johnson, J.E. and Cingolani, G. (2011) Three-dimensional structure of a viral genome-delivery portal vertex. Nature Struc Mol Biol. 18(5):597-603. PMCID: PMC3087855

37. Tang, J., Lander, G., Olia, A.S, Prevelige Jr., P.E., Cingolani, G., Casjens, S., Baker, T.S. and Johnson, J.E. (2011) Peering down the barrel of a bacteriophage portal – the genome packaging and release valve in P22. Structure. 19(4):496-502. PMCID: PMC3075339

36. Koksal, C.A. and Cingolani, G. (2011) Dimerization of Vaccinia virus VH1 is essential for dephosphorylation of STAT1 at tyrosine 701. J Biol Chem. 286(16):14373-82. PMCID: PMC3077637

35. Roy, A., Bhardwaj, A., and Cingolani, G. (2011) Crystallization of the Nonameric Small Terminase Subunit of Bacteriophage P22. Acta Cryst. F. 67, 104-110. PMCID: PMC3079985

34. Lott, K. and Cingolani, G. (2011) The IBB-domain as a master regulator of nucleocytoplasmic transport. Biochim Biophys Acta. 1813(9):1578-92. PMCID: PMC3037977

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2010

33. Nardozzi, J., Lott, K. and Cingolani, G. (2010) Phosphorylation meets Nuclear Import: a review. Cell Communication and Signaling. 8(1):32. PMCID: PMC3022542

32. Nardozzi, J., Wenta, N., Yasuhara, N., Vinkemeier, U. and Cingolani, G. (2010) Molecular basis for the recognition of phosphorylated STAT1 by importin a5. J. Mol. Biol. 402(1):83-100. PMCID: PMC2930068

31. Bhardwaj, A. and Cingolani, G. (2010) Conformational selection in the recognition of snurportin IBB-domain by importin b. Biochemistry 49(24):5042-7. PMCID: PMC6013741

30. Lott, K., Bhardwaj, A., Mitrousis, G., Pante, N., and Cingolani, G. (2010) The importin beta binding domain modulates avidity of importin b for the nuclear pore complex. J. Biol. Chem. 285(18):13769-80. PMCID: PMC2859540

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2009

29. Bhardwaj, A., Walker-Kopp, N., Casjens, S.R., and Cingolani, G. (2009) An evolutionarily conserved family of virion tail needles related to bacteriophage P22 gp26: correlation between structural stability and length of the a-helical trimeric coiled-coil. J. Mol. Biol. 391(1):227-45. PMCID: PMC2713385

28. Mitrea, D.M., Butler, J.S., Mitrousis, G., Cingolani, G. and Loh, S. N. (2009). Structural and Thermodynamic Analysis of Conformationally-Strained Circular Permutants of Barnase. Biochemistry.  PMCID: PMC275661448(15):3497-507.

27. Koksal, A., Nardozzi, J., and Cingolani, G. (2009) Dimeric quaternary structure of the prototypical dual specificity phosphatase VH1. J. Biol. Chem. 284(15):10129-37. PMCID: PMC2665067

26. Olia, S.A., Casjens, S., and Cingolani, G. (2009) Structural Plasticity of the phage P22 tail-needle gp26 probed with Xenon Gas. Protein Science. 18(3):537-548. PMCID: PMC2760360

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2008

25. Olia, S.A., and Cingolani, G. (2008) A shifty stop for a hairy tail. Mol. Microbiology, 70(3):549-53. PMCID: PMC2779026

24. Bhardwaj, A., Walker-Kopp N, Wilkens, S., and Cingolani, G. (2008) Foldon-guided self-assembly of ultra stable protein fibers. Protein Science 17(9):1475-85. PMCID: PMC2525528

23. Lorenzen, K., Olia, S.A., Uetrecht, C., Cingolani, G., and Heck, A.J.R. (2008). Determination of stoichiometry and conformational changes in the first step of the P22 tail assembly. J. Mol. Biol. 379(2):385-96. PMCID: PMC2768609

22. Mitrousis, G., Olia, S.A., Walker and Cingolani, G. (2008). Molecular basis for the recognition of snurportin 1 by importin b. J. Biol. Chem. 283(12):7877-84. PMID: 18187419

21. Zheng, H., Olia, S.A., Hankins, M., Andrews, S., Cingolani, G., and Gonen, T, (2008). A conformational switch in bacteriophage P22 portal protein primes genome injection. Molecular Cell. 29(3), 376-383. PMCID: PMC3936403

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2007

20. Olia, S.A., Casjens, S. and Cingolani, G. (2007) Structure of Phage P22 Cell Envelope Penetrating Needle. Nature Struc Mol Biol. 14(12), 1221-1226.

19. Olia, S.A., Bhardwaj, A., Joss, L., Casjens, S., and Cingolani, G. (2007) The role of gene 10 protein in the hierarchical assembly of the bacteriophage P22 portal vertex structure. Biochemistry. 46(30), 8776-8784.

18. Bhardwaj, A., Olia, S.A., Walker-Kopp N, and Cingolani, G. (2007) Domain organization and polarity of tail needle gp26 in the portal vertex structure of bacteriophage P22. J. Mol. Biol. 371(2), 374-87.

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2006

17. Olia, A., Al-Bassam, J., Winn-Stapley, D.A., Joss, L., Casjens, S., and Cingolani, G. (2006) Binding induced stabilization and oligomerization of portal closure factor gp4 in the assembly pathway of phage P22 tail. J. Mol. Biol. 363, 558–576.

16. Cingolani, G., Andrews, D., and Casjens, S. (2006) Crystallogenesis of bacteriophage P22 tail accessory factor gp26 at acidic and neutral pH. Acta Cryst. F 62, 477–482.

15. Taylor, D.J., Speir, J.A., Reddy, V., Cingolani, G., Pringle, F.M., Ball, L.A. and Johnson, J.E. (2006) Preliminary X-ray characterization of authentic providence virus and attempts to express its coat protein gene in recombinant baculovirus. Arch Virol. 151(1):155-65.

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2005

14. Andrews D, Butler JS, Al-Bassam J, Joss L, Winn-Stapley DA, Casjens S, and Cingolani, G. (2005) Bacteriophage P22 Tail Accessory Factor GP26 Is a Long Triple-stranded Coiled-coil. J. Biol. Chem. 280(7): 5929-33.

13. Chen MH, Ben-Efraim I, Mitrousis G, Walker-Kopp N, Sims PJ, and Cingolani, G. (2005) Phospholipid scramblase 1 (PLSCR1) contains a non-classical nuclear localization signal with unique binding site in importin a. J. Biol. Chem. 280(11):10599-606.

12. Tang L., Marion W., Cingolani, G., Prevelige P.E. Jr., and Johnson J.E. (2005) Three-dimensional structure of the bacteriophage P22 tail machine EMBO J. 24(12):2087-95.

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2004 - 2001

11. Wodrich, H., Guan, T., Cingolani, G., von Seggern, D., Nemerow, G., and Gerace, L. (2003). Switch from capsid protein import to adenovirus assembly by cleavage of nuclear transport signals. EMBO J. 22 (23): 6150-6162.

10. Bednenko, J., Cingolani, G., and Gerace, L. (2003). Importin beta contains a COOH-terminal nucleoporin binding region important for nuclear import. J. Cell Biol. 162(3): 391-401. Faculty of 1000 “recommended read”.

9. Koerner, C., Guan, T., Gerace, L. and Cingolani, G. (2003). Synergistic effects of silent and hot spot mutations in importin b reveals a dynamic mechanism for recognition of a nuclear localization signal. J. Biol. Chem. 278 (18): 16216-16221.

8. Cingolani, G., and Gerace, L. (2003). Molecular basis of nucleocytoplasmic transport. Handbook of Cell Signaling, Academic Press, Vol. 3(330): 419-429.

7. Bednenko, J., Cingolani, G., and Gerace, L. (2003). Nucleocytoplasmic transport: navigating the channel (NPC). Traffic, 4(3): 27-135.

6. Cingolani, G., Bednenko, J., Gillespie, M., and Gerace, L. (2002). Molecular basis for the recognition of a non-classical nuclear localization signal (NLS) by importin b. Molecular Cell, 10: 1345-1353.

5. Cingolani, G., Moore, S., Privilege, P.E., and Johnson, J. (2002). Preliminary crystallographic analysis of the bacteriophage P22 portal protein. J. Struc. Biology, 139: 46-54.

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2000 - 1997

4. Cingolani, G., Lashuel, H., Gerace, L., and Mueller, C.W. (2000). Nuclear import factors importin a and importin b undergo mutually induced conformational changes upon association. FEBS Lett., 484(3): 291-298.

3. Chook, Y.M, Cingolani, G., Conti, E., Stewart, M., Vetter, I., and Wittinghofer, A. (1999). Pictures in cell biology. Structures of nuclear-transport components. Trends Cell Biol., 9(8): 310-311

2. Cingolani, G., Petosa, C., Weis, K., and Mueller, C.W. (1999). Structure of importin b bound to the IBB domain of importin a. Nature, 399(6733): 221-229.

1. Cingolani, G., Capaccio, L., D'Elia, D., and Gadaleta, G. (1997). In organello footprinting analysis of rat mitochondrial DNA: protein interaction upstream of the Ori-L. Biochem Biophys Res Commun, 231(3): 856-860.

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